You know the usual song: means, motive, opportunity.
If a president makes enemies—big ones—they have a motive to get rid of him. Sure, to most of us that's weird. But that's because we're closer to normal than are the people in politics and D.C. I've been there several times. You think they are normal? Hardly.
So all you have to do is ask: who might Kennedy have ticked off? He had sex with many women. Yep, that would do it. He gave the Rothchilds a hard time. Yep. He made his brother attorney general. Yep. He reneged on deals with the mafia. Yep, that's a big one. He refused to go along with the CIA's nutty ideas. Yep, that's a big one, too. He was anti-Communist. He was Catholic. He was in bad health.
Who knows what else?
Who wanted to kill Jeff Epstein? Who didn't want to kill Jeff Epstein? He ran a blackmail business. He angered people for a living.